| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371987 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Guided by the metabolism information of SQ109, derivatives with substituted geranylamine moiety or substituted admantane ring of SQ109 were synthesized and evaluated as antituberculosis agents. Among all tested compounds, compound 11c showed the most potent antituberculosis activity with MIC value of 0.3 μM against Mycobacterium tuberculosis H37Rv.
Graphical abstractGuided by the metabolism information of SQ109, derivatives with substituted geranylamine moiety or substituted admantane ring of SQ109 were synthesized and evaluated as antituberculosis agents. Among all tested compounds, compound 11c showed the most potent antituberculosis activity with MIC value of 0.3 μM against Mycobacterium tuberculosis H37Rv.Figure optionsDownload full-size imageDownload as PowerPoint slide
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