| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371993 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
We synthesized and isolated 2α-substituted analogs of 14-epi-previtamin D3 after thermal isomerization at 80 °C for the first time. The VDR binding affinity and transactivation activity of osteocalcin promoter in HOS cells were evaluated, and the 2α-methyl-substituted analog was found to have greater genomic activity than 14-epi-previtamin D3.
Graphical abstract2α-Substituted analogs of 14-epi-previtamin D3 showed greater genomic activity than 14-epi-previtamin D3 such as the VDR binding affinity and transactivation activity of osteocalcin promoter in HOS cells.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Daisuke Sawada, Tomoyuki Katayama, Yuya Tsukuda, Nozomi Saito, Masashi Takano, Hiroshi Saito, Ken-ichiro Takagi, Eiji Ochiai, Seiichi Ishizuka, Kazuya Takenouchi, Atsushi Kittaka,