| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371998 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
In this study, we synthesized some natural and semi-synthetic prenyloxyphenylpropanoids (e.g., acetophenones, benzoic and cinnamic acids, chalcones, and coumarins), and we assessed their in vivo neuroprotective activity, using the mouse maximal electroshock-induced seizure model (MES test). 7-Isopentenyloxycoumarin and (2E)-3-{4-[(3-methylbut-2-enyl)oxy]phenyl}prop-2-enoic acid, administered ip at a dose of 300 mg/kg, suppressed MES-induced seizures in mice in a time- and dose-dependent manner.
Graphical abstractThe synthesis and neuroprotective activity (MES test) of selected prenyloxyphenylpropanoids is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Salvatore Genovese, Francesco Epifano, Massimo Curini, Monika Dudra-Jastrzebska, Jarogniew J. Luszczki,