| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372001 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
A series of dihydropyrid-2-ones was synthesized and tested for inhibitory activity against serine protease enzymes. Moderate to low nanomolar inhibitory activities were obtained against thrombin and excellent selectivity against trypsin was observed.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Stephen Hanessian, Eric Therrien, Jianbin Zhang, Willem van Otterlo, Yafeng Xue, David Gustafsson, Ingemar Nilsson, Ola Fjellström,