| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372013 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
We have investigated the ability of a previously reported antimicrobial peptide dendrimer (RW)4D to inactivate Escherichia coli RP437 in planktonic culture and in biofilms. The results show that the dendrimer inhibits bacterial growth in both planktonic and biofilm states. Live/Dead staining assays reveal that most bacteria in a preformed biofilm lose viability after treatment with this peptide. This result is in marked contrast to most existing reports that antimicrobial peptides are ineffective against mature bacterial biofilms.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Shuyu Hou, Chunhui Zhou, Zhigang Liu, Anne W. Young, Zhengshuang Shi, Dacheng Ren, Neville R. Kallenbach,