| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372015 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
Potent 5-HT2A inverse-agonists containing phenyl-pyrazole ureas with an amino side chain were identified. Optimization of this series resulted in selective compounds that proved effective in modulating 5HT-induced amplification of ADP-stimulated human platelet aggregation.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Peter I. Dosa, Sonja Strah-Pleynet, Honnappa Jayakumar, Martin Casper, Marc Decaire, Yifeng Xiong, Juerg Lehmann, Karoline Choi, Katie Elwell, Amy Wong, Robert R. Webb, John W. Adams, Juan Ramirez, Jeremy G. Richman, William Thomsen, Graeme Semple,