| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372017 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
A series of gibberellin based molecules were designed and synthesized. Gibberellin derivatives bearing two α,β-unsaturated ketone units showed strong anticancer activities in MTT assay towards a number of human cancer cell lines including HT29, A549, HepG2 and MKN28. The most potent gibberellin derivative (compound 10, IC50 = 2.9 μM against HT29) inhibited completely the topoisomerase I activity at 8 μg/mL level.
Graphical abstractA series of gibberellin based molecules were designed and synthesized. Gibberellin derivatives bearing two α,β-unsaturated ketone units showed strong anticancer activities in MTT assay towards a number of human cancer cell lines including HT29, A549, HepG2 and MKN28. The most potent gibberellin derivative (R = Me, IC50 = 2.9 μM against HT29) inhibited completely the topoisomerase I activity at 8 μg/mL level.Figure optionsDownload full-size imageDownload as PowerPoint slide
