Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1372035 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
The synthesis of a new series of 4-N-piperazinyl-thieno[2,3-d]pyrimidines is described. The synthetic route allows introducing structural variety at positions 2, 4 and 6 of the scaffold. Evaluation of their immunosuppressive activity in a Mixed Lymphocyte Reaction (MLR) assay revealed that the most potent compound has an IC50-value of 66 nM and therefore deserves attention for further medicinal chemistry optimization.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Mi-Yeon Jang, Steven De Jonghe, Kristien Van Belle, Thierry Louat, Mark Waer, Piet Herdewijn,