| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372043 | Bioorganic & Medicinal Chemistry Letters | 2010 | 6 Pages |
Abstract
Structure-guided drug design led to the identification of a class of spirocyclic ureas which potently inhibit human 11β-HSD1 in vitro. Lead compound 10j was shown to be orally bioavailable in three species, distributed into adipose tissue in the mouse, and its (R) isomer 10j2 was efficacious in a primate pharmacodynamic model.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Colin M. Tice, Wei Zhao, Zhenrong Xu, Salvacion T. Cacatian, Robert D. Simpson, Yuan-Jie Ye, Suresh B. Singh, Brian M. McKeever, Peter Lindblom, Joan Guo, Paula M. Krosky, Barbara A. Kruk, Jennifer Berbaum, Richard K. Harrison, Judith J. Johnson,