| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372050 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
Bridged monobactam β-lactamase inhibitors were prepared and evaluated as potential partners for combination with imipenem to overcome class C β-lactamase mediated resistance. The (S)-azepine analog 2 was found to be effective in both in vitro and in vivo assays and was selected for preclinical development.
Graphical abstractBridged monobactam β-lactamase inhibitors were prepared and evaluated as potential partners for combination with imipenem to overcome class C β-lactamase mediated resistance. The (S)-azepine analog 2 was found to be effective in both in vitro and in vivo assays and was selected for preclinical development.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Authors
Timothy A. Blizzard, Helen Chen, Seongkon Kim, Jane Wu, Katherine Young, Young-Whan Park, Amy Ogawa, Susan Raghoobar, Ronald E. Painter, Nichelle Hairston, Sang Ho Lee, Andrew Misura, Tom Felcetto, Paula Fitzgerald, Nandini Sharma, Jun Lu, Sookhee Ha,