| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372052 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Acetylated (Ac) dendrimer poly(amido)-amine (PAMAM) generation 5 (G5) reacted with folic acid (FA), followed by reacting with 2-(p-isothiocyanatobenzyl)-6-methyl-diethylenetria minepentaacetic acid (1B4M DTPA) to form the conjugate of Ac-G5-FA-1B4M DTPA which was further radiolabeled with 99mTc. The radiochemical yield is up to 98.9% with excellent in vitro/in vivo stability, rapid blood clearance and certain tumor accumulation which was further confirmed by micro-SPECT imaging study.
Graphical abstract99mTc radiolabeled acetylated (Ac) dendrimer poly(amido)amine (PAMAM) generation five (G5)-folic acid (FA)-2-(p-isothiocyanatobenzyl)-6-methyl-diethylenetria minepentaacetic acid (1B4M DTPA) to form the conjugate of 99mTc-Ac-G5-FA-1B4M DTPA with quantitative radiochemical yield. Furthermore the radioactive conjugate is excellent in vitro/in vivo stability, rapid blood clearance and certain tumor accumulation which was further confirmed by micro-SPECT imaging study.Figure optionsDownload full-size imageDownload as PowerPoint slide
