| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372059 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
With the aim of developing new SPECT imaging agents for the translocator protein (TSPO), a small library of iodinated quinoline-2-carboxamides have been prepared and tested for binding affinity with TSPO. N,N-Diethyl-3-iodomethyl-4-phenylquinoline-2-carboxamide was found to have excellent affinity (Ki 12.0 nM), comparable to that of the widely used TSPO imaging agent PK11195.
Graphical abstractA new library of iodinated quinoline-2-carboxamides has been prepared and tested for affinity with the translocator protein (TSPO). N,N-Diethyl-3-iodomethyl-4-phenylquinoline-2-carboxamide was found to have excellent affinity with a Ki value of 12.0 nM.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Louise Stevenson, Adriana A.S. Tavares, Aurélie Brunet, Fiona I. McGonagle, Deborah Dewar, Sally L. Pimlott, Andrew Sutherland,