Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1372065 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
A series of novel pyrazino[2,1-a]isoquinolin compounds were designed and synthesized, and their antifungal activities in vitro were evaluated. The results showed that all of the compounds exhibited antifungal activities. Some of them exhibited stronger antifungal activities than that of lead compounds and among them compound 11b was the most potent one, which showed more potent than that of the active control fluconazole to the four of the five tested fungi. The studies presented here provide a new structural type for the development of novel antifungal agents.
Graphical abstractThe mode of action of compound 13a with the active site of CYP51 of Candida albicans is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hui Tang, Canhui Zheng, Jiaguo Lv, Juan Wu, Yanan Li, Hui Yang, Bingyue Fu, Chuntong Li, Youjun Zhou, Ju Zhu,