Design, synthesis and studies of triphosphate analogues for the production of anti AZT-TP antibodies

Triphosphates anabolites are the active chemical species of nucleosidic reverse transcriptase inhibitors in HIV-therapy. Herein, we describe (i) the design of stable triphosphate analogues of AZT using molecular modelling, (ii) their synthesis and (iii) their use for producing anti AZT-TP antibodies in the aim of developing an immunoassay for therapeutic drug monitoring.

Graphical abstractThis Letter describes the design of stable triphosphate analogues of AZT using molecular modelling, their synthesis and their use for producing anti AZT-TP antibodies for developing an immunoassay for TDM.Figure optionsDownload full-size imageDownload as PowerPoint slide