| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372086 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
A new series of cyclic sulfonamide derivatives was synthesized and evaluated for their ability to inhibit 11β-HSD1. Cyclic sulfonamides with phenylacetyl substituents at the 2-position showed nanomolar inhibitory activities. Among them, compound 4e exhibited a good in vitro inhibitory activity and selectivity toward human 11β-HSD2.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Se Hoan Kim, Ravirala Ramu, Sung Wook Kwon, Su-Hee Lee, Chi Hyun Kim, Seung Kyu Kang, Sang Dal Rhee, Myung Ae Bae, Sung Hoon Ahn, Duck Chan Ha, Hyae Gyeong Cheon, Ki Young Kim, Jin Hee Ahn,