Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1372099 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
To identify novel non-nucleoside DNA methyltransferase (DNMT) inhibitors, we designed and synthesized a series of maleimide derivatives. Among this series, compounds 5–8 were found to be more potent DNMT1 inhibitors than RG108, a DNMT1 inhibitor reported previously by Siedlecki et al. The binding mode analysis of compound 5 is also reported.
Graphical abstractTo identify novel non-nucleoside DNA methyltransferase (DNMT) inhibitors, we designed and synthesized a series of maleimide derivatives. Among this series, compounds 5–8 were found to be more potent DNMT1 inhibitors than RG108, a DNMT1 inhibitor reported previously by Siedlecki et al.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Takayoshi Suzuki, Rikako Tanaka, Shohei Hamada, Hidehiko Nakagawa, Naoki Miyata,