Synthesis and structure–activity relationships of novel furazan-3,4-diamide analogs as potent anti-cancer agents

This study describes the synthesis and structure–activity relationships of a series of furazan-3,4-diamide analogs. 1,2,5-Oxadiazole ring and electron-withdrawing substituent on the phenyl ring are proposed to be the important elements which contribute to a significant extent maximal potency of anti-proliferation effect.

Graphical abstractSchematic representation of structure–activity relationships based on diverse furazan-3,4-diamide analogs.Figure optionsDownload full-size imageDownload as PowerPoint slide