Article ID Journal Published Year Pages File Type
1372110 Bioorganic & Medicinal Chemistry Letters 2010 4 Pages PDF
Abstract

Based on structural information for a peptide (P8-2KAQ) that binds to granulocyte-colony stimulating factor receptor (G-CSFR), small ligands with a biaryl scaffold were designed and their binding affinities were evaluated.

Graphical abstractThe synthesis of ligand 4 binds to G-CSF receptor is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide

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Physical Sciences and Engineering Chemistry Organic Chemistry
Preview
Molecular design of small organic molecules based on structural information for a conformationally constrained peptide that binds to G-CSF receptor
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