| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372129 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
We improved the specific radioactivity of the apoptosis imaging isatin derivative 18F-ICMT11. We then evaluated 18F-ICMT11 in EL4 tumor-bearing mice 24 h after treatment with etoposide/cyclophosphamide combination therapy. Dynamic PET imaging demonstrated increased uptake in the drug-treated (0.115 ± 0.011 SUV) compared to the vehicle-treated EL4 tumors (0.083 ± 0.008 SUV). This effect correlated to the observed increases in apoptotic index.
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Related Topics
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Organic Chemistry
Authors
Matthias Glaser, Julian Goggi, Graham Smith, Matthew Morrison, Sajinder K. Luthra, Edward Robins, Eric O. Aboagye,