Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1372140 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
We examined the impact of gradual removal of hydroxyl groups from the A- and B-rings of (−)-epicatechin gallate on antibacterial activity and oxacillin resistance attenuation of an epidemic strain of methicillin resistant Staphylococcusaureus. Removal of both hydroxyls from the B-ring effected a large reduction in oxacillin MIC (from 512 to 0.25 mg/mL at a concentration of 12.5 mg/L); further hydroxyl deletion of the A-ring reduced the oxacillin effect but increased intrinsic anti-staphylococcal activity
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
James C. Anderson, Robert A. McCarthy, Sarah Paulin, Peter W. Taylor,