| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372141 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
A new class of MCHR1 antagonists was discovered via a high-throughput screen. Optimization of the lead structure resulted in the identification of indole 10e. This compound possesses good pharmacokinetic properties across preclinical species and is efficacious in reducing food consumption in an MCH cannulated rat model and a cynomolgus monkey food consumption model.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jeffrey T. Mihalic, Xiaoqi Chen, Pingchen Fan, Xi Chen, Ying Fu, Lingming Liang, Michael Reed, Liang Tang, Jin-Long Chen, Juan Jaen, Leping Li, Kang Dai,