Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1372145 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
2-(1-Naphthalenylethynyl)-2′-deoxyadenosine (NA) was synthesized and incorporated into oligodeoxynucleotides. DNA duplexes containing newly designed 5′-NAT-3′/3′-TNA-5′ base pairs are considerably stabilized than unmodified duplexes by stacking interaction of naphthalene rings in the narrow minor groove as characterized by a new emission at longer wavelength and exciton coupled CD signals.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Makiko Tanaka, Ryota Kozakai, Yoshio Saito, Isao Saito,