| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372149 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
From the methanol extract of the bulbs of Pancratium illyricum L., three phenanthridine type alkaloids, ungeremine (1), (−)-lycorine (2) and (+)-vittatine (3) were isolated. For the evaluation of their anticancer and antibacterial potential, compounds 1–3 were tested against human (I, IIα) and bacterial (IA, IV) topoisomerases. Our data demonstrated that ungeremine impairs the activity of both, human and bacterial topoisomerases. Remarkably, ungeremine was found to largely increments the DNA cleavage promoted by bacterial topoisomerase IA, a new target in antimicrobial chemotherapy.
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Related Topics
Physical Sciences and Engineering
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Organic Chemistry
Authors
Laura Casu, Filippo Cottiglia, Marco Leonti, Alessandro De Logu, Emanuela Agus, Yuk-Ching Tse-Dinh, Valentina Lombardo, Claudia Sissi,