Synthesis and SAR of 2-Phenoxypyridines as novel c-Jun N-terminal kinase inhibitors

The design and synthesis of a novel series of c-jun N-terminal kinase (JNK3) inhibitors is described. The development and optimization of the 2-phenoxypyridine series was carried out from an earlier pyrimidine series of JNK1 inhibitors. Through the optimization of the scaffold 2, several potent compounds with good in vivo profiles were discovered.

Graphical abstractThe design and synthesis of a novel series of c-jun N-terminal kinase (JNK) inhibitors is described. The development of the 2-phenoxypyridine series was discovered from an earlier pyrimidine series of JNK inhibitors. Through the optimization of the scaffold 5, several potent compounds with good in vivo profiles were developed.Figure optionsDownload full-size imageDownload as PowerPoint slide