Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1372158 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
It was previously reported that DHAP-dependent aldolase RhaD selectively chooses l-glyceraldehyde from racemic glyceraldehyde to produce l-fructose exclusively. Contrastingly, we discovered that d-glyceraldehyde is also tolerated as an acceptor and the stereoselectivity of the enzyme is lost in the corresponding aldol addition. Furthermore, we applied this property to efficiently synthesize two rare sugars d-sorbose and d-psicose.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Zijie Li, Li Cai, Qingsheng Qi, Peng George Wang,