| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372170 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
Dibrominated resorcinol dimers were synthesized by reaction of 4-bromoresorcinol with aldehydes under reflux in ethanol in the presence of HCl. Subsequent dehalogenation yielded the corresponding monobrominated compounds and a fully dehalogenated dimer. Of the dimers, 6,6′-((4-hydroxyphenyl)methylene)bis(4-bromobenzene-1,3-diol) (4) displayed potent antibacterial activity and inhibitory activity against isocitrate lyase Candida albicans.
Graphical abstractThe synthesis and antimicrobial activities of brominated resorcinol dimers are described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Elise Bouthenet, Ki-Bong Oh, Seungil Park, Navjeet K. Nagi, Hyi-Seung Lee, Susan E. Matthews,