Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1372179 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
(+)-proto-Quercitol (1) and (−)-vibo-quercitol (2), both of which could be readily prepared by the bioconversion of myo-inositol, were successfully converted into the corresponding 4-methylenecyclohex-5-ene-1,2,3-triol derivatives. These compounds were demonstrated to be suitable precursors, preserving their configurations, for bioactive carba-aminosugars such as the potent chemical chaperone drug candidates, N-octyl-4-epi-β-valienamine (NOEV, 3) and N-octyl-β-valienamine (NOV, 4).
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Shinichi Kuno, Atsushi Takahashi, Seiichiro Ogawa,