| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372184 | Bioorganic & Medicinal Chemistry Letters | 2011 | 6 Pages |
Abstract
GalR1 and GalR2 represent unique pharmacological targets for treatment of seizures and epilepsy. A novel series of 2,4,6-triaminopyrimidine derivatives were synthesized and found to have sub-micromolar affinity for GalR2. Optimization of a series of 2,4,6-triaminopyrimidines led to the discovery of several analogs with IC50 values ranging from 0.3 to 1 μM.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Vasudeva Naidu Sagi, Tianyu Liu, Xiaoying Lu, Tamas Bartfai, Edward Roberts,