| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372195 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Pyrazolyl isoxazolines and isoxazoles were synthesised in moderate to good yields using 1,3-dipolar cycloaddition of pyrazole derived nitrile oxide with various dipolarophiles such as N-substituted maleimide, diethylacetylene dicarboxylate and phenylacetylene. The synthesized compounds were evaluated for antinociceptive activities. The 3-pyrazolyl-4,5-dicarbethoxy isoxazoles (9a–c) exhibited the maximum antinociceptive activity.
Graphical abstractPyrazolyl isoxazolines and isoxazoles were synthesised in moderate to good yields using 1,3-dipolar cycloaddition of pyrazole derived nitrile oxide with various dipolarophiles such as N-substituted maleimide, diethylacetylene dicarboxylate and phenylacetylene. The synthesized compounds were evaluated for antinociceptive activities. The 3-pyrazolyl-4,5-dicarbethoxy isoxazoles (9a–c) exhibited the maximum antinociceptive activity.Figure optionsDownload full-size imageDownload as PowerPoint slide
