Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1372198 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
A facile synthesis of six 4-iodophenyl tagged sphingosine (SP) derivatives bearing alkyl chain lengths from 6 to 13 is described. The key steps for the assembly of these molecules, 5a–f, are Suzuki–Miyaura cross-coupling and cross-metathesis reactions. The feasibility of radiolabeling was demonstrated by synthesizing two 125I labeled compounds, [125I]5c and [125I]5e. In vitro enzyme assays indicated that the molecules, 5c–e, are potent inhibitors. Thus, they deserve further evaluation as potential radioactive probes for tumor imaging.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Wenchao Qu, Karl Ploessl, Hong Truong, Mei-Ping Kung, Hank F. Kung,