| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372204 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
A peptide nucleic acid (PNA)-cell-penetrating peptide (CPP) conjugate (carrier PNA) was used as ‘bridge-builder’ to connect a CPP with an shRNA. The carrier PNA successfully formed a hybrid with an shRNA bearing complementary dangling bases and the shRNA was introduced into cells by the carrier PNA, and RNAi was induced by the shRNA.
Graphical abstractA peptide nucleic acid conjugated to a cell-penetrating peptide (carrier PNA) sequence-specifically binds to an shRNA bearing complementary dangling bases, and the carrier PNA delivers the shRNA effectively into cells.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Mizuki Kitamatsu, Takanori Kubo, Rino Matsuzaki, Tamaki Endoh, Takashi Ohtsuki, Masahiko Sisido,