Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1372205 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
A series of new 9-O-substituted berberine derivatives (4a–j) as telomeric quadruplex ligands was synthesized and evaluated. The results from biophysical and biochemical assay indicated that introducing of positive charged aza-aromatic terminal group into the side chain of 9-position of berberine significantly improved the binding ability with G-quadruplex, and exhibited the inhibitory effect on the hybridization and on telomerase activity. These derivatives showed excellent selectivity for telomeric G-quadruplex DNA over duplex.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yan Ma, Tian-Miao Ou, Jia-Heng Tan, Jin-Qiang Hou, Shi-Liang Huang, Lian-Quan Gu, Zhi-Shu Huang,