| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372208 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
We successfully discovered peptidomimetic motilin antagonists (17c and 17d) through the improvement of physicochemical properties of a tetrapeptide antagonist (2). Furthermore, with oral administration and based on motilin antagonistic activity, both compounds suppressed motilin-induced colonic and gastric motility in conscious dogs.
Graphical abstractPeptidomimetic motilin antagonists (17c and 17d) were identified. Both compounds dose-dependently suppressed motilin-induced colonic and gastric motility in conscious dogs.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Organic Chemistry
Authors
Naoki Taka, Hiroharu Matsuoka, Tsutomu Sato, Hitoshi Yoshino, Ikuhiro Imaoka, Haruhiko Sato, Ken-ichiro Kotake, Yoshikazu Kumagai, Kenshi Kamei, Ken-ichi Ozaki, Atsuko Higashida, Toshio Kuroki,