Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1372210 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
The design and synthesis of 2,6-diphenylthiazolo[3,2-b][1,2,4]triazoles characterized by a large aromatic building block bearing cationic side chains are reported. These molecules are evaluated as telomeric G-quadruplex stabilizers and for their selectivity towards duplex DNA by competition experiments. Two compounds (14a, 19) were found active with high selectivity for telomeric G-quadruplex over duplex DNA.
Graphical abstractTwo of the title compounds (14a, 19) bearing cationic side chains present high selectivity for telomeric G-quadruplex over duplex DNA.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jamal El Bakali, Frédérique Klupsch, Aurore Guédin, Bertrand Brassart, Gaëlle Fontaine, Amaury Farce, Pascal Roussel, Raymond Houssin, Jean-Luc Bernier, Philippe Chavatte, Jean-Louis Mergny, Jean-François Riou, Jean-Pierre Hénichart,