Article ID Journal Published Year Pages File Type
1372210 Bioorganic & Medicinal Chemistry Letters 2009 5 Pages PDF
Abstract

The design and synthesis of 2,6-diphenylthiazolo[3,2-b][1,2,4]triazoles characterized by a large aromatic building block bearing cationic side chains are reported. These molecules are evaluated as telomeric G-quadruplex stabilizers and for their selectivity towards duplex DNA by competition experiments. Two compounds (14a, 19) were found active with high selectivity for telomeric G-quadruplex over duplex DNA.

Graphical abstractTwo of the title compounds (14a, 19) bearing cationic side chains present high selectivity for telomeric G-quadruplex over duplex DNA.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Authors
, , , , , , , , , , , , ,