Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1372214 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
The bis-pharmacophore approach applied to neonicotinoid insecticides reveals high binding affinity for heptamethylene bis-N3,N3′-imidacloprid fitting a nicotinic acetylcholine receptor model wherein the chloropyridine moieties contact loops E and F and the alkylene linker bridges these two distant domains.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ikuya Ohno, Motohiro Tomizawaa, Kathleen A. Durkin, John E. Casida, Shinzo Kagabu,