Article ID Journal Published Year Pages File Type
1372231 Bioorganic & Medicinal Chemistry Letters 2009 6 Pages PDF
Abstract

A serendipitous discovery that the metalloprotease binding profile of a novel class of 2-carboxamide-3-hydroxamic acid piperidines could be significantly attenuated by the modification of the unexplored P1 substituent enabled the design and synthesis of a novel 2-carboxamide-1-hydroxamic acid cyclohexyl scaffold core that exhibited excellent HER-2 potency and unprecedented MMP-selectivity that we believe would not have been possible via conventional P1′ perturbations.

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Physical Sciences and Engineering Chemistry Organic Chemistry
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