| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372250 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
A novel compound inhibiting HIV-1 integrase has been identified by means of virtual screening techniques. A small family of structurally related molecules has been synthesized and biologically evaluated with some of the compounds possessing micromolar activity both in enzymatic and cellular assays.
Graphical abstractA novel compound inhibiting HIV-1 integrase has been identified by means of virtual screening techniques. A small family of structurally related molecules has been synthesized and biologically evaluated with some of the compounds possessing micromolar activity both in enzymatic and cellular assays.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Suvi Rajamaki, Anna Innitzer, Chiara Falciani, Cristina Tintori, Frauke Christ, Myriam Witvrouw, Zeger Debyser, Silvio Massa, Maurizio Botta,