Article ID Journal Published Year Pages File Type
1372256 Bioorganic & Medicinal Chemistry Letters 2009 5 Pages PDF
Abstract

A new series of benzothiazine-substituted quinolinediones were evaluated as inhibitors of HCV polymerase NS5B. SAR studies on this series revealed a methyl sulfonamide group as a high affinity feature. Analogues with this group showed submicromolar potencies in the HCV cell based replicon assay. Pharmacokinetic and toxicology studies were also performed on a selected compound (34) to evaluate in vivo properties of this new class of inhibitors of HCV NS5B polymerase.

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Physical Sciences and Engineering Chemistry Organic Chemistry
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