| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372420 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
First total synthesis of methylgerambullone (MGB, 1) isolated from Glycosmis angustifolia was completed via a convergent route. The effect of MGB on the contractile responses of the isolated guinea-pig ileum induced by acetylcholine was investigated. As a result, it showed a potent relaxation rate (78.66 ± 4.30% at 100 mg/L) in a concentration-dependent manner on longitudinal smooth muscle contraction of isolated guinea-pig ileum induced by 1 μM acetylcholine.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jong Taik Moon, Sung Hoon Ha, So Hyung Lee, Tae Hui Kwon, Chun Rim Oh, Young Deuk Kim, Jungahn Kim, Dong Joon Choo, Jae Yeol Lee,