In vitro and in vivo anti-Leishmania activity of polysubstituted synthetic chalcones

The in vitro screening of 43 polysubstituted chalcones against Leishmania amazonensis axenic amastigotes, led to the evaluation of 9 of them in a macrophage-infected model with the two other most infectious Leishmania species prevalent in Peru (L. braziliensis and L. peruviana). The five most active and selective chalcones were studied in vivo, resulting on the identification of two chalcones with high reduction parasite burden percentages.

Graphical abstractThe in vitro screening of 43 polysubstituted chalcones against Leishmania amazonensis axenic amastigotes, lead to the evaluation of nine of them in a macrophage-infected model with the two other most infectious Leishmania species prevalent in Peru (Leishmania braziliensis and Leishmania peruviana), five of the most active and selective were studied in vivo, resulting on the identification of two chalcones with high reduction parasite burden percentages.Figure optionsDownload full-size imageDownload as PowerPoint slide