Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1372432 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
A series of α7 neuronal nicotinic acetylcholine receptor ligands were designed based on a structural combination of a potent, but non-selective ligand, epibatidine, with a selective lead structure, 2. Three series of compounds in which aryl moieties were attached via a linker to different positions on the core structure were studied. A potent and functionally efficacious analog, (3aR,6aS)-2-(6-phenylpyridazin-3-yl)-5-(pyridin-3-ylmethyl)octahydropyrrolo[3,4-c]pyrrole (3a), was identified.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kathleen H. Mortell, Michael R. Schrimpf, William H. Bunnelle, David J. Anderson, Jens Halvard Gronlien, Kirsten Thorin Hagene, Murali Gopalakrishnan,