Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1372434 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
We have identified a novel series of ring-fused pyrazole derivatives as lymphocyte-specific kinase (Lck) inhibitors. The most potent analogs exhibited good enzyme inhibitory activity (IC50s <1 nM) as well as excellent cellular activity against mixed lymphocyte reaction (MLR) (IC50s <1 nM).
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Tetsuo Takayama, Hiroki Umemiya, Hideaki Amada, Tetsuya Yabuuchi, Takeshi Koami, Fumiyasu Shiozawa, Yusuke Oka, Akiko Takaoka, Akie Yamaguchi, Mayumi Endo, Masakazu Sato,