| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372445 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
A series of tetrahydro-β-carbolines were identified by HTS as inhibitors of the kinesin Eg5. Molecular modeling and medicinal chemistry techniques were employed to explore the SAR for this series with a focus of removing potential metabolic liabilities and improving cellular potency.
Graphical abstractA series of tetrahydro-β-carbolines were identified by HTS as inhibitors of the kinesin Eg5. Molecular modeling and medicinal chemistry techniques were employed to explore the SAR for this series with a focus of removing potential metabolic liabilities and improving cellular potency.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Paul A. Barsanti, Weibo Wang, Zhi-Jie Ni, David Duhl, Nathan Brammeier, Eric Martin, Dirksen Bussiere, Annette O. Walter,