Solid-phase synthesis and antibiotic activities of cyclodecapeptides on the scaffold of naturally occurring Laterocidin

Laterocidin and its analogues 1-6 were synthesized by solid-phase techniques with side chain carboxyl group of Aspartate linked to Rink resin by using Dmab group as a temporary α-COOH protecting group during solid-phase synthesis with Fmoc chemistry. Laterocidin analogue 3 exhibits potent and broad antibacterial activities.