Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1372463 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
Reverse cholesterol transport (RCT) is believed to be the primary mechanism by which HDL and its major protein apoA-I protect against atherosclerosis. Starting from the inactive 22-amino acid peptide representing the consensus sequence of the class A amphipathic helical repeats of apoA-I, we designed novel peptides able to mobilize cholesterol from macrophages in vitro, and to stimulate the formation of ‘nascent HDL’ particles, with potency comparable to the entire apoA-I protein.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Raffaele Ingenito, Charlotte Burton, Annunziata Langella, Xun Chen, Karolina Zytko, Antonello Pessi, Jun Wang, Elisabetta Bianchi,