Synthesis and antitumor activity of novel 2′,3′-dideoxy-2′,3′-diethanethionucleosides bearing 1,2,3-triazole residues

A series of novel 2′,3′-dideoxy-2′,3′-diethanethioribonucleosides and those modified with a triazole ring were prepared in excellent yields and their antitumor activity was evaluated. Nucleosides with a triazole ring, 16a–16c, showed significantly improved activity towards a broad range of tumor cell lines.

Graphical abstractA serires of novel 2′3′-dideoxy-2′,3′-diethanethioribonucleosides with triazole ring were prepared and their antitumour activity was evaluated.Figure optionsDownload full-size imageDownload as PowerPoint slide