| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372466 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
A range of 3,4-alkylated five-membered ring derivatives of gabapentin were synthesised. One compound (21) had an excellent level of potency against α2δ and was profiled in in vivo models of pain and anxiety.
Graphical abstractA range of 3,4-disubstituted gababutins were synthesised and, of these, the stand-out compound was (21). This compound was profiled in in vivo models of pain and anxiety.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
David C. Blakemore, Justin S. Bryans, Pauline Carnell, Mark J. Field, Natasha Kinsella, Jack K. Kinsora, Leonard T. Meltzer, Simon A. Osborne, Lisa R. Thompson, Sophie C. Williams,