| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372472 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
AP18 1 was recently disclosed as an antagonist of the TRPA1 receptor by the research group of Patapoutian. However, no detailed structure–activity relationships around 1 have been disclosed. Thus, a small number of oximes related to AP18 were examined in order to characterize the determinants of TRPA1 activity. Congeners of AP18 were found to possess both agonist and antagonist activity, suggesting that AP18 may behave as a covalent antagonist of the TRPA1 ion-channel.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jeff DeFalco, Daniel Steiger, Amy Gustafson, Daniel E. Emerling, Michael G. Kelly, Matthew A.J. Duncton,