| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372492 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
A structure–activity relationship study was conducted of several CD4 mimicking small molecules which block the interaction between HIV-1 gp120 and CD4. These CD4 mimics induce a conformational change in gp120, exposing its co-receptor-binding site. This induces a highly synergistic interaction in the use in combination with a co-receptor CXCR4 antagonist and reveals a pronounced effect on the dynamic supramolecular mechanism of HIV-1 entry.
Graphical abstractCD4 mimic small molecules interacting with a large cavity of HIV-1 gp120, which are targeted for the dynamic supramolecular mechanism of HIV entry, are reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yuko Yamada, Chihiro Ochiai, Kazuhisa Yoshimura, Tomohiro Tanaka, Nami Ohashi, Tetsuo Narumi, Wataru Nomura, Shigeyoshi Harada, Shuzo Matsushita, Hirokazu Tamamura,