Article ID Journal Published Year Pages File Type
1372494 Bioorganic & Medicinal Chemistry Letters 2010 4 Pages PDF
Abstract

A range of 3-alkylated five-membered ring derivatives of Gabapentin were synthesized and several were found to have good levels of potency against the α2δ calcium subunit of a voltage-gated calcium channel. Two compounds were profiled in in vivo models of pain and anxiety.

Graphical abstractA range of 3-alkylated five-membered ring derivatives of Gabapentin were synthesized and several were found to have superior potency against the α2δ calcium subunit. Diastereoisomeric compounds, (16) and (22), were profiled in in vivo models of pain and anxiety and proved to have different levels of efficacy in the two models.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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